Toxic Evaluation of Subchronic Exposure to Cadmium, Imidacloprid, and their Combination on Hematological Parameters in Buffalo Calves

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Authors

  • Tsewang Dorjay
     Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141012, Punjab
  • Harpal Singh Sandhu
     Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141012, Punjab
  • Rajdeep Kaur
     Department of Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana - 141012, Punjab

DOI:

https://doi.org/10.22506/ti/2015/v22/i3/137624

Keywords:

Buffalo Calves, Cadmium, Imidacloprid, Subchronic, Toxicity.

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Volume 22, Issue 3, September-December 2015 || Original Articles

How to Cite

Dorjay, T., Sandhu, H. S., & Kaur, R. (2015). Toxic Evaluation of Subchronic Exposure to Cadmium, Imidacloprid, and their Combination on Hematological Parameters in Buffalo Calves. Toxicology International (Formerly Indian Journal of Toxicology), 22(3), 46–51. https://doi.org/10.22506/ti/2015/v22/i3/137624
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The present investigation was undertaken to evaluate hematological alterations induced by oral subchronic exposure to cadmium, imidacloprid, and their combination in buffalo calves. Cadmium exposure produced a significant decrease in hemoglobin (Hb) concentration, Total Erythrocyte Count (TEC), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and MCH Concentration (MCHC). There was a significant increase in Total Leukocyte Count (TLC) but it did not produce any change in Erythrocyte Sedimentation Rate (ESR). Repeated oral administration of imidacloprid produced a significant decrease in Hb, PCV, TEC, MCV, MCH, and MCHC; however, there was a significant elevation in the levels of ESR and TLC. The combined exposure of cadmium and imidacloprid produced a significant decline in Hb concentration, PCV, TEC, MCV, and MCHC. It produced a significant increase in ESR and TLC, but no changes were observed in the levels of MCH.

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